Zinc is a fundamental mineral that can be found in almost every cell of the human body. It regulates the immune system by helping cells to kill the virus, microbes, and other harmful organisms.
Taurine, or 2-aminoethanesulfonic acid, is an organic acid found in almost all tissues in mammals, playing various important physiological roles in each organ.
- Taurine exhibits an antioxidant effect, as to significantly decrease lipid peroxidation and to increase the activities of the antioxidant enzymes
- It is also known to have effects on cell proliferation, inflammation and collagen genesis.
Zinc-Taurine combination for therapeutic purposes can be justified because of two possibilities of therapeutic benefits:
- Zinc and Taurine possess, separately, favorable properties which contribute to the therapeutic benefit (additive effect).
- The combination of Zinc and Taurine gives rise to favorable properties, not possessed by the components separately (synergistic effect).
The anti-inflammatory properties of Zinc gluconate, Taurine or their combination as a complex was investigated using a Caco-2 (epithelial) in vitro cell assay. In this study monolayer Caco-2 cells were grown in culture. Cells were then treated with Doxorubicin, Lipopolysaccharide (LPS) or Dextran Sulfate Sodium (DSS). Serial dilutions of Zinc gluconate, Taurine or a mixture of Zinc-Taurine were delivered as a complex. Following an incubation period, cell culture supernatants were evaluated for expression of IL-6 and IL-8, two pro-inflammatory cytokines associated with aphthous ulcers and oral mucositis lesions.
The results of this study demonstrated that Zinc gluconate and Taurine inhibited IL-6 and IL-8 expression in a dose dependent manner. The experiment also revealed that the monodentate/bidentate Zinc-Taurine complex was superior inhibiting IL-6 and IL-8 compared to Zinc gluconate alone or Taurine alone.
BMG Pharma holds a patent on the mineral salt-sulfonic acid composition (ZINC and TAURINE) and method of use in several therapeutic areas like Gynecology and Oral Care.