IALUVANCE COMPLEX™ is a proprietary association of hyaluronic acid, hydrogen peroxide and glycine.
- Hyaluronic Acid plays a fundamental role in every phase of tissue repair, including inflammation, cell migration, angiogenesis, re-epithelialization and has a film genic ability
- Hydrogen Peroxide has the high antibacterial, antiviral and anti-mycotic action
- Glycine is able to accelerate the cutaneous barrier repair.
A product based on IALUVANCE COMPLEX™ maintains a moist environment that is conducive to healing, by either absorbing wound exudate or donating moisture. Thanks to its antimicrobial agents, it inhibits the growth of micro-organisms.
Key ingredients work synergistically to create the highly protective and filmogenous barrier.
HA is found in many tissues of the body and is a major component of the extracellular matrix. It is involved in numerous physiological processes, such as cell proliferation, cellular function, tissue hydration, and joint lubrication.
HA also plays a fundamental role in every phase of tissue repair, including inflammation, cell migration, angiogenesis, re-epithelialization and scar formation due to its physico-chemical (hygroscopic, rheological and viscoelastic) and biological properties. Hyaluronic acid-based medications have been found to facilitate wound repair and have proved more effective than growth factors in promoting healing while also reducing scar formation.
Subsequently, HA has become widely used not only to improve wound healing, but also as a medical treatment and prevention for a large number of the following connective tissue disorders and problems: fractures, hernias, glaucoma, keratoconus, detached retinas, osteoarthritis, TMJ, vocal cord insufficiency, cartilage damage, and ligament healing. Moreover, it provides soothing relief of dryness, itching, and burning of the skin.
Hydrogen peroxide is a chemical compound that acts as a mild antiseptic and comes in various potencies.
It has strong oxidation in order to disinfect the wound tissue; it is also useful for removing cellular and pathogenic debris and promotes the secretion of cytokines that promote tissue regeneration.
H2O2 facilitates hemostasis by different mechanisms that include activation of different tissue growth factors, promotion of platelet aggregation, and regulation of contractility and barrier function of endothelial cells.
H2O2 can improve the expression of inflammation related genes and the synthesis of proinflammatory cytokines including TNF-a, IL-1B, IL-5 IL-8 and IFN-a.
Glycine is a non-essential amino acid and has anti-inflammatory, cytoprotective and immunomodulation properties.
It is a fundamental component of several important biological molecules, such as collagen and acts as a biosynthetic intermediate in numerous metabolic reactions.
Current research has demonstrated that endothelial and epithelial cells contain glycine-dependent chlorine channels and that when these channels are stimulated, cutaneous barrier repair is accelerated, indicating that glycine plays a crucial role in skin barrier homeostasis.