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Sodium Hyaluronate Lipoate Silver (SHLS)

is a biomaterial based on the patented Hyaluromimethic® Technology (i.e., sodium hyaluronate modified on its hydroxylic bonds). Biologically active silver ions in SHLS are the key in the formation of a 3D matrix with barrier activity against different strains of bacteria and biofilm growth without affecting the cells.

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Description

SHLS is an outstanding biocompatible biomaterial with unique viscoelastic properties and a three-dimensional matrix made of polysaccharides.

The chemical affinity of the components in SHLS and their balance brings tailored characteristics to the products that help to improve its applications.

Unmatched Benefits of SHLS

  • The addition of Lipoate to SH creates a unique radical scavenger.
  • SHL exhibits high viscoelasticity
  • Enhanced film-forming property
  • Improved resistance to enzymatic degradation
  • Silver ions in SHLS exert activity against Gram-Positive and Gram-Negative bacteria.
  • The affinity between the components creates a 3D network with strong viscoelastic properties.
  • Its unique properties and the antimicrobial feature are the key factors for a broad range of applications with barrier effect against bacteria and reduction of biofilm growth.

Applications

Clinical Data

VISCOSITY IN SOLUTION IN VITRO PERCUTANEOUS STUDIES

SHL 37

SHL shows an exponential enhancement in viscosity at very low concentrations.
In vitro experiments on percutaneous absorption show the absence of permeation through the cutaneous layer of SHL.
These aspects, as fundamental elements for a strong barrier effect, allow SHL to be a vital ingredient in protecting integument tissues.

ANTIINFLAMMATORY ACTIVITY

nmol
adhesion

SHL reduces the adhesion of PMN onto their surface, typical behavior of an anti-inflammatory agent.

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