SHLS – Sodium Hyaluronate Lipoate Silver

What it is

The barrier against bacteria and biofilm
Sodium Hyaluronate Lipoate Silver (SHLS) is a functional ingredient based on the patented Hyaluromimethic Technology (i.e. sodium hyaluronate modified on its hydroxylic bonds).
It is an outstanding biocompatible biomaterial with unique viscoelastic properties and a three-dimensional matrix made of polysaccharides.

THE SAME PATH BUT DIFFERENT RESULTS

SAME EFFICENCY

What it does

Silver ions present in SHLS exert activity against antibiotic-resistant bacteria, such as GRAM+ and GRAM–.

 

The affinity between the components creates a 3D network with strong viscoelastic properties. The rheological profile and the antimicrobial activity are key factors to a broad range of applications, as medical devices have a barrier effect against bacteria and reduce biofilm growth.

 

The chemical affinity of the components and their balance brings tailored characteristics to the products that help to improve the possible applications.

Clinical studies & tests

ACTIVITY AGAINST GRAM+ AND GRAM BACTERIA

The silver ions act against a broad range of bacteria and reduce their growth rate which helps to retain its activity over time.

ACTIVITY ON BACTERIAL BIOFILM  

No bacterial growth was observed at very low concentrations after 4h from the addition of SHLS on the biofilm.

CITOTOXICITY  

Measures of cytotoxicity of BALB 3T3 in different solutions show the complete absence of cytotoxicity, even at concentrations higher than those active against bacteria and biofilm growth.

Conclusion

Biological Active Silver Ions in SHLS are key to the formation of a 3D matrix with barrier activity against different strains of bacteria and on biofilm growth without affecting cells.

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